Vaccines show promise for Marburg, Ebola

WINNIPEG – Canadian and US scientists have developed vaccines that protect monkeys from the deadly Marburg and Ebola viruses and show promise for humans, a study published in Nature Medicine magazine said.

It will take five or six years to complete the research to show the experimental vaccines can be safe and effective for people exposed to the contagious viruses, which are almost always fatal, said Steven Jones, one of the Canadian-based scientists behind the study. “The data would suggest that instead of 100 per cent chance of dying, they would have an 80 per cent chance of survival,” Jones told reporters.It is the first sign of success for a Marburg vaccine.Dutch company Crucell is working on commercialising a different type of Ebola vaccine.Marburg and Ebola viruses are spread by bodily fluids including blood, sweat and saliva.Most victims die within days after massive bleeding.Jones and collaborator Heinz Feldmann have been part of an international relief effort for the world’s worst outbreak of Marburg virus in Uige, Angola, where 335 of 399 people who contracted the disease had died as of May 26, according to the World Health Organisation.There is no vaccine or treatment other than drugs to relieve pain for victims, said Jones, who will return to Angola this week.”One of the most nasty, foul things about this disease is that it is spread by close contact,” he said, noting it often kills relatives of the ill.”If you could use this vaccine in the field and vaccinate family members of known cases, you could be protecting those people who are putting their lives at risk for their loved ones,” Jones said.Work on the vaccine began more than three years ago at Canada’s National Microbiology Laboratory in Winnipeg, Manitoba.Jones and Feldmann replaced a protein in an animal virus with a protein from the Ebola and Marburg viruses, and successfully tested the vaccines on rodents.The US Army Medical Research Institute of Infectious Disease in Maryland injected monkeys with the vaccines, and then 28 days later with the viruses.The monkeys survived.”The data would suggest that instead of 100 per cent chance of dying, they would have an 80 per cent chance of survival,” Jones told reporters.It is the first sign of success for a Marburg vaccine.Dutch company Crucell is working on commercialising a different type of Ebola vaccine.Marburg and Ebola viruses are spread by bodily fluids including blood, sweat and saliva.Most victims die within days after massive bleeding.Jones and collaborator Heinz Feldmann have been part of an international relief effort for the world’s worst outbreak of Marburg virus in Uige, Angola, where 335 of 399 people who contracted the disease had died as of May 26, according to the World Health Organisation.There is no vaccine or treatment other than drugs to relieve pain for victims, said Jones, who will return to Angola this week.”One of the most nasty, foul things about this disease is that it is spread by close contact,” he said, noting it often kills relatives of the ill.”If you could use this vaccine in the field and vaccinate family members of known cases, you could be protecting those people who are putting their lives at risk for their loved ones,” Jones said.Work on the vaccine began more than three years ago at Canada’s National Microbiology Laboratory in Winnipeg, Manitoba.Jones and Feldmann replaced a protein in an animal virus with a protein from the Ebola and Marburg viruses, and successfully tested the vaccines on rodents.The US Army Medical Research Institute of Infectious Disease in Maryland injected monkeys with the vaccines, and then 28 days later with the viruses.The monkeys survived.